Mandibular Involvement Associated With Segmental Odontomaxillary Dysplasia: A Case Series.

Segmental odontomaxillary dysplasia (SOD) is an uncommon and likely underrecognized developmental condition. In rare cases, SOD can also result in anomalies of the ipsilateral mandibular alveolar process and teeth. This report presents two cases of SOD with mandibular involvement to highlight this potential variation in SOD presentation. These cases help shed new light on our understanding of the disease mechanism and pathoetiology, while also informing clinicians to be diligent in imaging the ipsilateral mandible for dental anomalies in their patients with SOD. Based on the involvement of both jaws, the name change to 'segmental ipsilateral odontognathic dysplasia' is justified to better reflect its pathophysiology.

Evaluation of Facial Profile Esthetics After Maxillomandibular Advancement Surgery for the Treatment of Obstructive Sleep Apnea.

PURPOSE: Maxillomandibuar advancement (MMA) surgery has been shown to be a successful treatment for obstructive sleep apnea (OSA), but concerns still exist regarding esthetic outcomes due to the large advancements involved. The objective of this study was to evaluate facial profile changes in patients who underwent MMA surgery for OSA by utilizing panels of external evaluators. METHODS: Pre- and posttreatment silhouettes of 21 patients (10 females, 11 males; mean age 43.2 [±11.5] years), who underwent MMA surgery for OSA, were generated from profile photographs. Utilizing survey software, the individual silhouettes were shown in random order to surgeons, orthodontists and laypeople, who assessed the esthetics of each via a sliding visual analogue scale (0 to 10). RESULTS: For all evaluators combined, postsurgical esthetic scores were significantly improved in 19 of 21 patients (P < .001). Ninety-five percent of evaluators judged the changes after surgery as positive or neutral. There was a mean increase in postsurgical esthetic scores of 1.9 [±1.9], which was moderately correlated with AHI changes (r = 0.48, P < .05). Mean esthetic score changes were significantly different between evaluator groups for 12 of 21 patients (P < .05), with surgeons and orthodontists reporting more positive change than laypeople. CONCLUSIONS: Overall, MMA surgery for the treatment of OSA does not have a negative impact on facial profile esthetics, with external evaluators judging the changes as favorable in the majority of patients assessed.

Septic Arthritis of the Temporomandibular Joint in a 10 Year Old: A Case Report and Literature Review.

Septic arthritis of the temporomandibular joint (TMJ) is extremely rare in the pediatric population, with only 9 cases reported in the English-language literature. This report presents a case of septic TMJ in a 10-year-old girl and a review of the literature for diagnostic criteria and management strategies.

Identifying Candidate Biomarkers for Pleomorphic Adenoma: A Case-Control Study.

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Kallikrein-related peptidases have been identified as biomarkers in many human tumors and may influence tumor behavior. We investigated KLK1-15 messenger ribonucleic acid and proteins in PA specimens to determine a KLK expression profile for this tumor. Fresh frozen PA tissue specimens (n = 26) and matched controls were subjected to quantitative real-time reverse transcription polymerase chain reaction to detect KLK1-15 mRNA. Expression of KLK1, KLK12, KLK13, and KLK8 proteins were then evaluated via immunostaining techniques. Statistical analyses were performed with the level of significance set at P < .05. We observed downregulation of KLK1, KLK12, and KLK13 mRNA expression, and immunostaining studies revealed downregulation of the corresponding proteins. Histologic evidence of capsular perforation was associated with increased KLK1 protein expression. Tumor size was not associated with capsular invasion and/or perforation. This study is the first to detail a KLK expression profile for PA at both the transcriptional level and the protein level. Future work is required to develop clinical applications of these findings.

Ultrasound-guided greater palatine nerve block: a case series of anatomical descriptions and clinical evaluations.

BACKGROUND: Greater palatine nerve (GPN) block is commonly performed for maxillary and palatal anesthesia by using bony landmarks. Ultrasound (US) can be used to consistently identify greater palatine foramen (GPF) as a defect in the bony palate enabling US-guided injections near the foramen. METHODS: We scanned and injected 16 undissected well-embalmed hemisectioned cadaveric heads after excluding major anatomical malformations. A linear high-frequency hockey stick probe (7-13 MHz) positioned in long axis to the hard palate visualized GPF as a discontinuity in the hard palate. US-guided injections of 0.1 mL India ink were made in an oblique plane. Specimens were dissected immediately after injection, and dye distribution was noted. The success rate of identification of GPF, number of attempts, and number of successful injections were recorded. The technique was evaluated clinically in 7 patients undergoing dental procedures. Five patients had US-guided injections, and 2 patients received US-assisted greater palatine canal blocks. RESULTS: GPF was successfully identified in 16 hemisectioned heads (n = 16). In 7 of 16 hemisectioned cadaveric specimens (n = 7/16), needle pass was seen on the US and traces of India ink were found within the greater palatine canal and pterygopalatine fossa. In the remaining heads (n = 9/16), the dye was observed in the mucosal tissue of the hard palate anterior to the GPF or in the soft palate. Clinical evaluation reconfirmed successful identification of GPF by US in 6 of 7 patients (n = 6/7). US-guided injections were successful in 6 of the 8 attempted blocks (n = 6/8) with median number (range) of attempts being 2 (1-4). US-assisted injections were successful in 2 patients (n = 2/2). CONCLUSIONS: US has the potential to successfully locate and characterize GPF in normal and edentulous maxilla. US-guided GPN blocks can be technically challenging. The clinical applicability of US guidance or assistance for GPN block needs further evaluation in a larger sample of patients.

Ameloblastic fibro-odontoma: a case report.

Ameloblastic fibro-odontoma is a benign epithelial odontogenic tumour with odontogenic mesenchyme exhibiting the histologic characteristics of ameloblastic fibroma and complex odontoma. It is usually associated with developing teeth and occurs predominantly in children and adolescents. In many cases, such lesions are found on radiographic evaluation of patients in whom eruption of teeth is delayed. Ameloblastic fibro-odontoma is generally asymptomatic but may cause swelling and discomfort. This report describes an ameloblastic fibro-odontoma in the posterior mandible of a 26-year-old woman and discusses the histogenesis and clinical features of the lesion.